Williams finished in the 149th place position with a time of 25:31 over the six kilometer race.
Nesbit ended her race just seven seconds and five places behind Williams with a time of 25:38 and 152nd place showing.
Number 3 and number 4 runners Victoria Dyson and Emma Leonhard both crossed the finish line within one second of each other, taking the 169th and 170th positions with times of 26:01 and 26:02.
Greenville's scoring was wrapped up by Sabrina Favela who was 210th in 27:39.
The Panthers concluded the race with 830 points in a field of 35 teams.
Greenville wrapped up the cross country season with the runner up position at the SLIAC championships.